3. Bibliografía

Abulafia O, Sherer DM. Angiogenesis in the uterine cervix Int J Gynecol Cancer. 2000;10(5):349-357.

Avall-Lundqvist EH, Silfversward C, Aspenblad U, Nilsson BR, Auer GU The impact of tumour angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival in squamous cervical carcinoma. Eur J Cancer. 1997; 33(11):1799-1804.

Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003 ;3(6):401-410.

Bibbo M, Longatto A. Aspectos Clínicos e Laboratoriais dos derrames cavitários:Conduta Terapêutica e Avaliações Diagnósticas e Prognosticas. Fernando C. Schmitt & Carla Costa. :Biologia Celular. 1th ed. Rio de Janeiro: Revinter, 2001

Bouvet M, Ellis LM, Nishizaki M, Fujiwara T, Liu W, Bucana CD, Fang B, Lee JJ, Roth JA. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer Cancer Res.1998;58(11):2288-2292.

Branca M, Giorgi C, Santini D, Di Bonito L, Ciotti M, Benedetto A, Paba P, Costa S, Bonifacio D, Di Bonito P, Accardi L, Favalli C, Syrjänen K; HPV-Pathogen ISS Study Group. Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer. J Clin Pathol. 2006;59(1):40-7.

Bremer GL, Tiebosch AT, van der Putten HW, Schouten HJ, de Haan J, Arends JW. Tumor angiogenesis: an independent prognostic parameter in cervical cancer. Am J Obstet Gynecol. 1996; 174(1 Pt 1):126-131.

Burbridge MF, Coge F, Galizzi JP, Boutin JA, West DC, Tucker GC. The role of the matrix metalloproteinases during in vitro vessel formation.Angiogenesis. 2002; 5(3):215-226.

Cantu MG, Marinetti E, Perego P, Valente MG, Urso M, Landoni F Retroperitoneal fibrosis localised to the pelvis, imitating a gynaecologic tumour.BJOG. 2003; 110(2):224-226.

Carmeliet P, Collen D.Molecular basis of angiogenesis. Role of VEGF and VE-cadherin. Ann

F, Calcinai A, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G. Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. Br J Cancer. 1999; 79(2):363-369.

Fox SB, Gasparini G, Harris AL. Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol. 2001; 2(5):278-89.

Fujiwaki R, Hata K, Iida K, Maede Y, Miyazaki K. Vascular endothelial growth factor expression in progression of cervical cancer: correlation with thymidine phosphorylase expression, angiogenesis, tumor cell proliferation, and apoptosis. Anticancer Res. 2000; 20(2B):1317-1322.

Gaffney DK, Haslam D, Tsodikov A, Hammond E, Seaman J, Holden J, Lee RJ, Zempolich K, Dodson M Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2003; 56(4):922-928.

Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, Meng G, Hong K, Marsters JC, Ferrara N. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.Nature. 2002; 417(6892):954-958.

Gombos Z, Xu X, Chu CS, Zhang PJ, Acs G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res. 2005;11(23):8364-71.

Hattori K, Heissig B, Wu Y, Dias S, Tejada R, Ferris B, Hicklin DJ, Zhu Z, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MA, Werb Z, Lyden D, Rafii S Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment Nat Med. 2002; 8(8):841-849.

Hawighorst H, Knapstein PG, Knopp MV, Weikel W, Schaeffer U, Zuna I, Schönberg SO, Essig M, Hoffmann U, Brix G, van Kaick G. [Angiogenesis of cervix carcinoma. Contrast enhanced dynamic MRI, histologic quantification of capillary density and lymphatic system infiltration] Radiologe. 1998; 38(1):50-57.

Höckel S, Schlenger K, Vaupel P, Hockel M. Association between host tissue vascularity and the prognostically relevant tumor vascularity in human cervical cancer Int J Oncol. 2001;1 9(4):827-832.

Joyce JA. Therapeutic targeting of the tumor microenvironment Cancer Cell. 2005; 7(6):513-520.

Kaku T, Hirakawa T, Kamura T, Amada S, Kinukawa N, Kobayashi H, Sakai K, Ariyoshi K, Sonoda K, Nakano H. Angiogenesis in adenocarcinoma of the uterine cervix Cancer. 1998; 83(7):1384-1390.

Kang JO, Hong SE. The prognostic effect of VEGF expression in squamous cell carcinoma of the cervix treated with radiation therapy alone. J Korean Med Sci. 2004; 19(5):693-697.

Kodama J, Seki N, Tokumo K, Hongo A, Miyagi Y,Yoshinouchi M. Vascular endothelial growth factor is implicated in early invasion in cervical cancer. Eur J Cancer 1999; 35(3):485-489.

Gynecol Oncol. 2003;89(3):414-419.

Safran M, Kaelin WG Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway J Clin Invest. 2003;111(6):779-783.

Santin AD, Hermonat PL, Ravaggi A, Pecorelli S, Cannot MJ, Parham GP. Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix. Obstet Gynecol 1999; 94(1): 78-82.

Schlenger K, Hockel M, Mitze M. Tumor vascularity: a novel prognostic factor in advanced cervical carcinoma. Gynecol Oncol 1995; 59: 57-66.

Sherif ZA, Nakai S, Pirollo KF, Rait A,Chang EH Downmodulation of bFGF-binding protein expression following restoration of p53 function. Cancer Gene Ther. 2001;8(10):771-782.

Tjalma W, Van Marck E, Weyler J, Dirix L, Van Daele A, Goovaerts G, Albertyn G, van Dam P. Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer.Br J Cancer. 1998;78(2):170-174.

Tjalma W, Weyler J, Weyn B, Van Marck E, Van Daele A, Van Dam P, Goovaerts G, Buytaert P. The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer.Eur J Obstet Gynecol Reprod Biol. 2000;92(2):251-257.

Tokumo K, Kodama J, Seki N, Nakanishi Y, Miyagi Y, Kamimura S, Yoshinouchi M, Okuda H, Kudo T. Different angiogenic pathways in human cervical cancers Gynecol Oncol. 1998;68(1):38-44.

Vermeulen PB, Roland L, Mertens V, Van Marck E, De Bruijn EA, Van Oosterom AT, Dirix LY Correlation of intratumoral microvessel density and

N Y Acad Sci. 2000; 902:249-262.

Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000; 407 (6801):249-257.

Cheng WF, Chen CA, Lee CN, Wei LH, Hsieh FJ, Hsieh CY Vascular endothelial growth factor and prognosis of cervical carcinoma. Obstet Gynecol. 2000; 96(5 Pt 1):721-726.

Cooper RA, West CM, Wilks DP, Logue JP, Davidson SE, Roberts SA, et al... Tumour vascularity is a significant prognostic factor for cervix carcinoma treated with radiotherapy: independence from tumour radiosensitivity. Br J Cancer 1999; 81(2):354-358.

Coskun U, Gunel N, Toruner FB, Sancak B, Onuk E, Bayram O, Cengiz O, Yilmaz E, Elbeg S, Ozkan S.Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer.Neoplasma. 2003; 50(1):41-46.

Dameron KM, Volpert OV, Tainsky MA, Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science. 1994; 265(5178):1582-1584.

Davidson B, Goldberg I, Gotlieb WH, Lerner-Geva L, Ben-Baruch G, Kopolovic J. Ulex Europaeus lectin and anti-CD31 staining in squamous cell carcinoma of the uterine cervix: potential prognostic markersInt J Gynecol Pathol. 1998; 17(3):205-210.

Dellas A, Moch H, Schultheiss E, Feichter G, Almendral AC, Gudat F, Torhorst J.Angiogenesis in cervical neoplasia: microvessel quantitation in precancerous lesions and invasive carcinomas with clinicopathological correlations. Gynecol Oncol. 1997; 67(1):27-33.

Dunst J, Kuhnt T, Strauss HG, Krause U, Pelz T, Koelbl H, Haensgen G Anemia in cervical cancers: impact on survival, patterns of relapse, and association with hypoxia and angiogenesisInt J Radiat Oncol Biol Phys. 2003; 56(3):778-787.

Ferrara N.Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25(4):581-611.

Folkman J.Fundamental concepts of the angiogenic process. Curr Mol Med. 2003;3(7):643-651.

Fontanini G, Boldrini L, Chine S, Pisaturo F, Basolo

Le Couter J, Moritz DR, Li B, Phillips GL, Liang XH, Gerber HP, Hillan KJ, Ferrara N.Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science. 2003;299(5608):890-893.

Lee IJ, Park KR, Lee KK, Song JS, Lee KG, Lee JY, Cha DS, Choi HI, Kim DH, Deung YK. Prognostic value of vascular endothelial growth factor in Stage IB carcinoma of the uterine cervix Int J Radiat Oncol Biol Phys. 2002;54(3):768-779.

Lee JS, Choi YD, Lee JH, Nam JH, Choi C, Lee MC, Park CS, Juhng SW, Kim HS, Min KW Expression of cyclooxygenase-2 in adenocarcinomas of the uterine cervix and its relation to angiogenesis and tumor growth Gynecol Oncol. 2004;95(3):523-529.

Lenczewski A, Terlikowski SJ, Sulkowska M, Famulski W, Sulkowski S, Kulikowski M. Prognostic significance of CD34 expression in early cervical squamous cell carcinoma. Folia Histochem Cytobiol. 2002;40(2):205-206.

Linderholm B, Tavelin B, Grankvist K, Henriksson R Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma J Clin Oncol. 1998;16(9):3121-3128.

Loncaster JA, Cooper RA, Logue JP, Davidson SE, Hunter RD, West CM Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. Br J Cancer. 2000;83(5):620-625.

Lyng H, Sundfor K, Rofstad EK. Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis. Int J Radiat Oncol Biol Phys. 2000;46(4):935-946.

Meyer T, Hart IR.Mechanisms of tumour metastasis. Eur J Cancer. 1998 ;34(2):214-221.

Mitsuhashi A, Suzuka K, Yamazawa K, Matsui H, Seki K, Sekiya S. Serum vascular endothelial growth factor (VEGF) and VEGF-C levels as tumor markers in patients with cervical carcinoma. Cancer. 2005;103(4):724-30.

Obermair A, Wanner C, Bilgi S, Speiser P, Kaider A, Reinthaller A, Leodolter S, Gitsch G. Tumor angiogenesis in stage IB cervical cancer: correlation of microvessel density with survival. Am J Obstet Gynecol. 1998;178(2):314-319.

Paley PJ, Staskus KA, Gebhard K, Mohanraj D, Twiggs LB, Carson LF, Ramakrishnan S Vascular endothelial growth factor expression in early stage ovarian carcinoma. Cancer. 1997;80(1):98-106.

Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A.Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 2000;14(1):34-44.

Rutgers JL, Mattox TF, Vargas MP. Angiogenesis in uterine cervical squamous cell carcinoma.Int J Gynecol Pathol. 1995;14(2):114-118.

Ryu SY, Oka K, Tsujii H, Suzuki Y, Nakano T. Platelet-derived endothelial cell growth factor as a prognostic factor for radiotherapy outcome in patients with adenocarcinoma of the uterine cervix

p53 protein overexpression in human colorectal adenocarcinoma. Microvasc Res. 1996;51(2):164-174.

Vieira SC, Zeferino LC, Silva BB, Santana JO, Santos LG, Carvalho TC, Rocha MC[Sentinel node study with patent blue in cervical cancer] Rev Assoc Med Bras. 2004;50(3):302-4.

West CM, Cooper RA, Loncaster JA, Wilks DP, Bromley M. Tumor vascularity: a histological measure of angiogenesis and hypoxia. Cancer Res. 2001;61(7):2907-2910.

Wiggins DL, Granai CO, Steinhoff MM. Tumor angiogenesis as a prognostic factor in cervical carcinoma. Gynecol Oncol 1995; 56: 353-356.

Yamamoto S, Konishi I, Mandai M, Kuroda H, Komatsu T, Nanbu K, Sakahara H, Mori T. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels. Br J Cancer. 1997;76(9):1221-1227.

Zaghloul MS, El Naggar M, El Deeb A, Khaled H, Mokhtar N Prognostic implication of apoptosis and angiogenesis in cervical uteri cancer Int J Radiat Oncol Biol Phys. 2000;48(5):1409-1415.

Zhang L, Yu D, Hu M, Xiong S, Lang A, Ellis LM, Pollock RE Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res. 2000;60(13):3655-3661.