5. Bibliografía

5.     Bibliografía

Alapetite C, Thirion P, de la Rochefordiere A, Cosset JM, Moustacchi E. Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: defective rejoining of radioinduced ADN strand breaks in lymphocytes of breast cancer patients. Int J Cancer 1999; 24; 83(1):83-90.

Barber J, West C, Kiltie A, Roberts S, Scott D. Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia-telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy. Radiat Res 2000; 153(5Pt1): 570-8.

Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M, Francz PI. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proceedings of the National Academy of Science. USA. 1988; 85(14):5112-6.

Borgmann K, Röper B, El-Awady R, Brackrock S, Bigalke M, Dörk T, Alberti W, Dikomey E, Dahm-Daphi J, et al.. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, ADN repair, and chromosome aberrations. Radiother Oncol. 2002; 64(2):141-52.

Burnet NG, Wurm R, Nyman J, Peacock J H. Normal tissue radiosensitivity-- how important is it? Clin Oncol 1996; 8(1):25-34.

Burnet NG, Wurm R, Peacock JH. Low dose-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy. Int J Radiat Biol 1996; 70(3):289-300.

Crompton NE, Ozhsahin M. A versatile and rapid assay of radiosensitivity of peripheral blood Leukocytes based on ADN and surface-Marker assessment of cytotoxicity. Radiat Res 1997; 147(1):55-60.

Crompton NE, Miralbell R , Rutz HP, Ersoy F, Sanal O, Wellmann D, Bieri S, Coucke PA, Emery GC, Shi YQ, Blattmann H, Ozsahin M. Altered apoptotic profiles in irradiated patients with increased toxicity. Int J Radiat Oncol Biol Phys 1999; 45(3): 707-14.

Crompton N, Shi YQ, Emery GC, Wisser L, Blattmann H, Maier A., Li L., Schindler D., Ozsahin H., Ozsahin M. Sources of variation in patient response to radiation treatment. Int J Radiat Oncol Biol Phys 2001; 49(2): 547-54.

Delanian S, Martin M, Bravard A, Luccioni C, Lefaix JL. Abnormal phenotype of cultured fibroblasts in human skin with chronic radiotherapy damage. Radiother Oncol 1998; 47(3):255-61.

Dörr W, HendryJH. Consequential late effects in normal tissues. Radiother Oncol. 2001; 61(3):223-31.

Geara FB, Peters LJ, Ang KK, Wike JL, Brock WA. Prospective comparison between in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys 1993; 27:1173-79.

Nachtrab U, Oppitz U, Flentje M, Stopper H. Radiation-induced micronucleous formation in human skin fibroblasts of patients showing severe normal tissue damage after radiotherapy. Int J Radiat Biol 1998; 73: 279-87.

Neubauer S, Dunst J, Gebhart E. The impact of complex chromosomal rearrangements on the detection of radiosensitivity in cancer patients. Radiother Oncol 1997; 43(2):189-95.

O'Driscoll MC, Scott D, Orton CJ, Kiltie AE, Davidson SE, Hunter RD, West CM. Radiation-induced micronuclei in human fibroblasts in relation to clonogenic radiosensitivity. Br J Cancer 1998; 78(12):1559-63.

Oppitz U, Denzinger S, Nachtrab U, Flentje M, Stopper H. Radiation-induced comet-formation in human skin fibroblasts from radiotherapy patients with different normal tissue reactions. Strahlenther Onkol 1999; 175(7):341-6.

Oppitz U, Baier K, Wuf J, Schakowski R, Flentje M. The in vito colony assay: A predictor of clinical outcome. Int J Radiat Biol 2001; 77:105-10.

Ozsahin M., Ozsahin H., Shi Y., Larsson B., Würgler F., Crompton N. Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 lymphocytes. Int. J. Radiat. Oncol. Biol. Phys.1997; 38(2): 429-40.

Ozhasin M, Crompton N, Gourgou S, Kramar A, Li L, Shi Y, Sozzi WJ, Zouhair A, Mirimanoff RO, Azria D.CD4 and CD8 T-Lymphocyte apoptosis can predict radiation-induced late toxicity: A prospective study in 399 patients. Clin Cancer Res 2005; 11(20):7426-33.

Peacock J, Ashton A, Bliss J, Bush C, Eady J, Jackson C, Owen R, Regan J, Yarnold J. Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother Oncol 2000; 55(2):173-8.

Philippé J., Louagie H., Thierens H., Vral A., Cornelissen M., De Ridder L. Quantification of apoptosis in lymphocyte subsets and effect of apoptosis on apparent expression of membrane antigens. Cytometry 1997; 29:242-49.

Pinar B, Lara PC, Lloret M, Bordon E, Nunez MI, Villalobos M, Guerrero R, Luna JD, Ruiz de Almodovar JM.Radiation-induced ADN damage as a predictor of long-term toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapy.Radiat Res. 2007 Oct;168(4):415-22.

Rached E, Schindler R, Beer KT, Vetterli D, Greiner RH. No predictive value of the micronucleous assay for patients with severe acute reaction of normal tissue after radiotherapy. Eur J cancer 1998; 34(3):378-83.

Ramsay J., Birrel G. Normal tissue radiosensitivity in breast cancer patients. Int J Radiol 1995; 31:339-44.

Rana R, Vitale M, Mazzotti G, Manzoli L, Papa S. Radiosensitivity of human natural killer cells : binding and cytotoxic activities of natural killer cell subsets. Radiat Res 1990; 124(1):96-102.

51(1):10-5.

Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. Ceramide activates the stress-activated protein kinases. J Biol Chem 1995; 270(39):22689-92.

Widel M, Jedrus S, Lukaszczyk B, Raczek-Zwierzycka K, Swierniak A. Radiation-induced micronucleus frequency in peripheral blood lymphocytes is correlated with

Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, Kolesnick RN. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.J Exp Med 1994; 180(2):525-35.

Herskind C, Bentzen SM, Overgaard J, Overgaard M, Bamberg M, Rodemann HP. Differentiation state of skin fibroblasts cultures versus risk of subcutaneous fibrosis after radiotherapy. Radiother Oncol 1998; 47 (3): 263-69.

Johansen J, Bentzen SM, Overgaard J, Overgaard M. Relationship between the in vitro radiosensitiviy of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia and skin erythema after radiotherapy. Radiother Oncol 1996; 40: 101-09.

Kearsley JH, Fang ZM, Clarke RA. Clinical radiohypersensitivity screening using radiation-induced chromosomal aberrations. Australas Radiol 1998; 42(3):219-21.

Kiltie AE, Barber JB, Swindell R, Ryan AJ, West CM, Hendry JH, Magee B. Lack of correlation between residual radiation-induced ADN damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients. Int J Radiat Oncol Biol Phys 1999;43(3):481-7.

Lara PC., Russell NS., Smolders IJH., Bartelink H., Begg AC., Coco-Martin JM. Radiation-induced differentiation of human skin fibroblasts: relationship with cell survival and collagen production. Int J Radiat Biol 1996; 70 (6): 683-92.

Loeffler JS, Harris JR, Dailberg WK, Little TJ. In vitro radiosensitivity of human diploid fibroblasts derived from woman with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. Radiat Res 1990; 121, 227-31.

López E, Guerrero R, Nunez MI, del Moral R, Villalobos M, Martinez-Galan J, Valenzuela MT, Munoz-Gamez JA, Oliver FJ, Martín-Oliva D, Ruiz de Almodóvar JM. Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced ADN damage in lymphocytes. Breast Cancer Res. 2005; 7(5):R690-8.

Mori M., Benotmane M.A., Tirone I., Hooghe-Peters E.L., Desaintes C. Transcriptional response to ionizing radiation in lymphocyte subsets.Cell. Mol. Life Sci.2005; 62(13)1489-1501.

Muller C., Dusseau C., Calsou P. and Salles B. Human normal peripheral blood B-lymphocytes are deficient in ADN-depend protein kinase activity due to the expression of a variant form of the Ku 86 protein. Oncogene 1998, 16 (12): 1553-60.

Muller WU, Bausch T, Stuben G, Sack H, Streffer C. Radiation sensitivity of lymphocytes from healthy individuals and cancer patients as measured by the comet assay. Radiat Environ Biophys. 2001; 40(1):83-9.

Rodemann HP., Peterson HP., Schwenke K., Von Wangenheim KH. Terminal differentiation of human fibroblasts is induced by radiation. Scanning Microscopy 1991; 5: 1135-42.

Russell NS., Lara PC., Grunmels A., Hart AM., Coco-Martin JM., Bartelink H., Begg AC. In vitro differentiation characteristics of human skin fibroblasts: correlation with radiotherapy induced breast fibrosis in patients. In J Radiat Biol 2000; 73 (6): 661-70.

Schmitz A, Bayer J, Déchamps N, Thomas G. Intrinsic susceptibility to radiation-induced apoptosis of human lymphocyte subpopulations. Int J Radiat Oncol Biol Phys 2003; 57(3):769-78.

Seki H., Kanegane H., Iwai K., Konno A., Ohta K., Yachie A., Taniguchi N., Miyawaki T. Ionizing radiation induces apoptotic cell death in human TcR-?/?+ T and natural killer cells without detectable p53 protein.Eur.J.Immunol 1994;24(11):2914-7.

Seki H, Iwai K, Kanegane H, Konno A, Ohta K, Yachie A, Taniguchi N, Miyawaki T. Differential protective action of cytokines on radiation-induced apoptosis of peripheral lymphocyte subpopulations. Cell Immunol 1995; 163(1):30-6.

Sheng-Tanner X, Bump EA, Hedley DW. An oxidative stress-mediated death pathway in irradiated human leukemia cells mapped using multilaser flow cytometry. Radiat Res 1998; 150(6):636-47.

Slonina D, Klimek M, Szpytma T, Gasinska A. Comparison of the radiosensitivity of normal-tissue cells with normal-tissue reactions after radiotherapy. Int J Radiat Biol 2000; 76(9):1255-64.

Stewart CC, Stevenson AP, Habbersett RC.The effect of low-dose irradiation on unstimulated and PHA-stimulated human lymphocyte subsets. Int J Radiat Biol Relat Stud Phys Chem Med 1988; 53(1):77-87.

Tepper AD, de Vries E, van Blitterswijk WJ, Borst J. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and ADN damage-induced apoptosis. J Clin Invest 1999; 103(7):971-8.

Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells 1998; 3(11):697-707.

Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996; 380(6569):75-9.

West C., Davidson S., Elyan S., Swindel R., Roberts S., Orton C., Coyle C., Valentine H., Wilks D., Hunter R., Hendry J. The intrinsic radiosensitivity of normal and tumor cells. Int. J. Radiat. Biol 1998; 73(4): 409-13.

West CM, Davidson SE, Elyan SA et al.. Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 2001;

normal tissue damage in patients with Cervical Carcinoma undergoing radiotherapy. Radiation Research 2003; 159:713-21.

Yamada S, Durante M, Ando K, Furusawa Y, Kawata T, Majima H, Tsujii H. Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity Cancer Lett 2000; 150(2):215-21.