9. BIBLIOGRAFÍA

Bartek J and Lukas J. Mammalian G1- and S-phase checkpoints in response to ADN damage. Curr Opin Cell Biol 2001; 13:738-747.

Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A,et al.. Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene 2000; 19(9):1181-1190.

Belka C, Schmid B, Marini P, Durand E, Rudner J, Faltin H, et al.. Sensitization of resistant lymphoma

Bonner JA, Raisch KP, Trummell HQ, Robert F, Meredith RF, Spencer SA et al.. Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J Clin Oncol. 2000; 18(21):47S-53S.

Brown EJ and Baltimore D: Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 2003; 17(5):615-628.

Campbell C, Quinn AG, Angus B, Farr PM, Rees JL. Wavelength specific patterns of p53 induction in human skin following exposure to UV-radiation.Cancer Res 1993; 53 (12):2697-2699.

Chinnaiyan AM, Prasad U, Shankar S, Hamstra DA, Shanaiah M, Chenevert TL, et al.. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci USA 2000; 97(4):1754-1759.

Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyllie AH. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 1994; 9(6): 1767-1773.

Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant ADN synthesis. Nature 2001; 410(6830):842-847.

Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, Arabshahi A, Major C, Deng C, Russo A, Mitchell JB, Roberts AB. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation.Am J Pathol. 2002;160(3):1057-68.

Huang SM. Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999; 59(8):1935-1940.

Komarov PG, Komarova EA, Kondratov RV, Christovtselkov K, Coon JS, Chernov MV, et al.. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999; 285(5434):1733-1737.

Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP, Hall PA. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994; 54(3): 614-617.

Meyer T, Regenass U, Fabbro D, Alteri E, Rösel J, Müller M, et al.. A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer 1989; 43(5): 851-856.

cells to irradiation-induced apoptosis by the death ligand TRAIL. Oncogene. 2001; 20(17):2190-2196.

Belka C and Budach W. Anti-apoptotic BCL-2 proteins:structure, function and relevance for radiation biology, Int J Radiat Biol 2002;78(8):643-658.

Belka C, Betsch A, Marini P, Jendrossek V, Bamberg M, Budach W. [Death inducing ligands in combination with ionizing radiation: objective and current knowledge]. Strahlenther Onkol 2003; 179(3):141-151.

Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Kolesnick R. Endotelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 2001; 293(5528):293-297.

Pyo H, Choy H, Amorino GP, Kim JS, Cao Q, Hercules SK, et al.. A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Clin Cancer Res 2001;7: (10):2998-3005.

Rothkamm K, Kruger I, Thompson LH, Lobrich M.Pathways of ADN double-strand break repair during the mammalian cell cycle.Mol Cell Biol. 2003 ;23(16):5706-5715.

Ryan KM, Phillips AC, Vousden KH. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 2001; 13(3):332-337.

Selzer E, Pimentel E, Wacheck V, Schlegel W, Pehamberger H, Jansen B, et al.. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. J Invest Dermatol 2000; 114(5): 935-940.

Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by ADN damage. Embo J 2003; 22(20):5612-5621.

Vousden KH, Lu X. Live or let die: the cell's

response to p53. Nat Rev Cancer. 2002;

2(8):594-604.

Walker JR, Corpina RA, Goldberg J. Structure of

the Ku heterodimer bound to ADN and its

implications for double-strand break repair. Nature

2001; 412(6847):607-614.

Weisberg E, Boulton C, Kelly LM, Manley P, Fabbro D, Meyer T et al.. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell 2002; 1(5): 433-443.

Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P.et al., atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nature Genet 1997; 16 (4), 397-401.

Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.Mol Cell Biol. 2002 ;22(4):1049-1059.

Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 2002; 16(5):571-582.